Ann, still affected by the abduction, is on sick-leave again. Len is appointed Acting Governor. The men influence the women's prison. Bobbie and Marlene become fond of Matt, who in his turn fancies Pixie. Frank tries to rape Bobbie, but is stopped by Geoff. A romance is flourishing between Myra and Geoff. Lou and Frank co-operate with drug dealing and similar things. Yemil tries to commit suicide, but is saved by Pixie. Lexie Patterson arrives on remand to Wentworth, accused of poker fraud. She knows Bobbie from earlier. Two gangsters dressed as handymen place a timed gasbomb in Geoff's and Matt's cell. It goes off during the night, but the men are saved by Meg and Joan. Bobbie is given release work as an electrician on daytime. Frank rapes Pixie. Joan and Myra agree to put the blame on Len, who is forced to resign and is arrested. Pixie is moved to mental hospital.
Meg has to go through a tumour operation and loses her expected baby. Dennis returns to Wentworth for work. Shane re-appears at Joan's after having escaped from his foster parents, Bob Taylor and Marnie Taylor, but she forces him to return to them. Bobbie is released and goes to live with Stan and Edie. Alcoholic lawyer Janice Grant is sentenced to Wentworth for drunk driving. Ettie Parslow is moved from Barnhurst to Wentworth. Dennis beats Joan in the election for Union representative. A sniper tries to shoot Geoff and Matt, but instead Joyce and Lexie are hit and slightly wounded. Marlene and Matt start a relation. Yemil is released. Lou tries to shoot Joan with a home-made gun and plans to put the blame on Myra, but the gun explodes and instead Lou herself is wounded. Janice is suffering from alcohol abstinence and buys any chemicals that Lou and Alice can provide her with as a substitute. Sam escapes in a children's toy robot that has been manufactured at Wentworth, to see her biological mother for the first time, but she rejects Sam who voluntarily returns to Wentworth. As punishment for Pixie's rape, Myra brands Frank in the forehead. False policemen try to kidnap the three men from Wentworth, but they are stopped by Joan and Dennis after a gunfight.
The music interested Sheila Brady is on remand at Wentworth, accused of drug crimes. Lou and Kath Deakin make a failed attempt to kill Myra. Sam tries to commit suicide, but is stopped by Joan. Janice discovers that Ettie has spent more than 40 years in prison without a trial. Lou and Alice try to kill Myra with electricity, but instead it is Sam who goes into the trap and is killed. Lou and Alice try to make it look like suicide, but the autopsy shows it was murder. Lou manages to put the whole blame on Alice. Ray is fired after being caught smuggling in alcohol to the prison. Matt proposes to Marlene and she accepts. Judy and Sheila start a musical co-operation. The co-operation between Lou and Frank finally breaks off and instead they become enemies. Major Ferguson dies. Frank tries to escape by taking Dennis hostage, but he is over-powered. Ray sends a revealing letter about Joan and Reb to Wentworth.
Mervin Pringle gets the job as prison cook with the help of false references. Andrew Fry is appointed as new Head of the Department. Janice is taken to sickbay after drinking another one of Alice's chemical mixtures. Ann and Sister Hall reveal her alcoholism. Janice undeliberately lags on Alice. The women reveal Mervin's incomptence, but they don't give him away because he treats them well. Ettie is released and compensated after Janice has pleaded her case. Lou and Kath make another failed attempt to kill Myra. Joan can keep her job after her officer friend at Blackmoor, Cynthia Leach, has put pressure on Reb. Meg reluctantly lets Ettie stay with her after the release.
Dennis takes up a young hitch-hiking girl. Soon after she is found murdered and Dennis becomes suspected of murdering 6 young girls. The nun Anita Selby serve sentence at Wentworth for violence against police at a peace demonstration. Sheila is released. As revenge for lagging, Janice is forced by Alice and Lexie to drink poison. She gets so sick she has to be taken to hospital and narrowly survives and doesn't come back to Wentworth. Detective Grace has Dennis arrested for the serial killings, but he is freed after a 7th murder to which he has an alibi. Judy is upset when she finds out that Sheila has stolen her "Pixie's Song" and made a career. Ettie moves to an elderly living. Frank tries to kill Joan, she survives but starts to have black-outs after the beat on the head. Frank is revengeful and makes a list of all people he is going to kill: Lou, Joan, Myra, Geoff and Matt. Judy reconciles with Sheila and becomes her song writer. Frank makes some more failed attempts to kill his enemies. Marlene and Matt are married in the prison garden. After the wedding, Matt is transferred to another prison, together with Frank who in a last statement adds Dennis to his death list.
Marlene is released. Judy is released. Geoff is released. Myra decides to use one of Joan's black-outs and bashes Lou to put the blame on Joan. Joan is fired. Anita gets second thoughts and tells Ann that Joan is innocent to Lou's bashing. Ann is most furious over Myra's acting and no longer recognizes her as the prisoners' spokeswoman. Joan gets her job back, but in the meantime she has been admitted to hospital and operated for her head injury. Anita is released. After all releases, the remaining women talk about old memories and episode 536 becomes a collection of flashbacks to older scenes in the series, of which many with Bea Smith. At the end of the episode, Meg is informed by Ann that there has been a riot at Barnhurst, the prison has been damaged by fire and Bea killed.